FOX and John Stamos will continue their working relationship.

After his series Grandfathered was recently cancelled after one season, it was announced today by FOX that Stamos has been cast in a series regular role in the upcoming second season of Scream Queens, the comedy-horror series from award-winning executive producers Ryan Murphy, Brad Falchuk and Ian Brennan.

The second season of Scream Queens will premiere on Tuesday, Sept. 20 (9:00-10:00 PM ET/PT).

The second season of the quirky series graduates from the college campus and into an all-new location, as a terrifyingly funny mystery will begin once again.

Set in a hospital, where some of the most fascinating and bizarre medical cases are under observation, Stamos will play Dr. Brock Holt, the hospital’s brilliant, but secretive, head surgeon.

As previously announced, Jamie Lee Curtis, Emma Roberts, Lea Michele, Abigail Breslin, Keke Palmer, Glen Powell and Niecy Nash are set to reprise their Season One characters. Additional casting to be announced.

**Photo courtesy of Tommy Garcia/FOX**

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